BISPECIFIC ANTIBODIES AND METHODS FOR THEIR PRODUCTION AND USE Russian patent published in 2023 - IPC A61K39/00 C07K16/28 C07K16/30 

FIELD: biotechnology.

SUBSTANCE: group of inventions is described, including a bispecific antibody specifically binding to α-CTLA4 and to α-PD-1 or α-PD-L1, isolated nucleic acid encoding a bispecific antibody, an expression vector, a host cell (options), a method for the production of a bispecific antibody, an immunoconjugate for the treatment of a subject with cancer sensitive to regulation of antigens of control points of CTLA4 and PD-1 or PD-L1, a pharmaceutical composition for the treatment of a subject with cancer sensitive to regulation of antigens of control points of CTLA4 and PD-1 or PD-L1 (options), a method for the treatment of a subject with cancer sensitive to regulation of antigens of control points of CTLA4 and PD-1 or PD-L1, including administration to a subject of effective amount of a bispecific antibody or a pharmaceutical composition, and the use of a bispecific antibody or a pharmaceutical composition for the treatment of a subject with cancer sensitive to regulation of antigens of control points of CTLA4 and PD-1 or PD-L1.

EFFECT: invention expands the arsenal of bispecific antibodies specifically binding to α-CTLA4 and to α-PD-1 or α-PD-L1.

30 cl, 12 dwg, 3 tbl, 12 ex