FIELD: biotechnology.
SUBSTANCE: invention relates to a bispecific antibody or a fragment of this bispecific antibody that binds to the transferrin receptor (TfR) and to a cell surface antigen, as well as to a method of its preparation. Also the following is disclosed: the DNA encoding the above antibody or a fragment thereof, as well as the vector and transformant containing it.
EFFECT: invention is effective for treating a disease associated with at least one of human TfR and EGFR, which is a cancer.
18 cl, 21 dwg, 7 tbl, 20 ex
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