FIELD: medicine; oncology.
SUBSTANCE: group of inventions can be used for treating soft tissue sarcoma and skin cancer. That is ensured by using a combination containing metformin and anti-pd-1 antibody. Group of inventions also relates to a method of treating and/or preventing cancer involving administering a combination.
EFFECT: use of said combination provides a synergetic effect, increasing sensitivity of immune cells to a therapeutic agent when treating them with an antidiabetic drug metformin, increasing multifunctionality of immune cells as a result of increase in the number of cd8+-t-cells, having the ability to produce il-2, tnfα and ifnγ.
5 cl, 8 ex, 5 tbl, 13 dwg
| Title |
Year |
Author |
Number |
| COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX CONTAINING A CELL-PENETRATING PEPTIDE, A CARGO MOLECULE, AND A TLR PEPTIDE AGONIST, FOR APPLICATION IN MEDICINE |
2017 |
- Derouazi Madiha
- Belnoue Elodie
|
RU2769314C1 |
| OBTAINING ANTIGEN-SPECIFIC T-CELLS |
2017 |
- Oelke, Mathias
- Santos, Jose, Luis
- Kim, Sojung
- Schneck, Jonathan
- Kosmides, Alyssa
|
RU2745319C2 |
| COMBINATION OF IMMUNE CHECKPOINT MODULATOR AND COMPLEX CONTAINING CELL-PENETRATING PEPTIDE, CARGO MOLECULE, AND TLR PEPTIDE AGONIST FOR MEDICAL USE |
2017 |
- Deruazi Madikha
- Belnu Elodi
|
RU2748378C2 |
| METHODS FOR INCREASING EFFECTIVENESS OF ANTITUMOUR IMMUNE RESPONSE |
2015 |
|
RU2689162C2 |
| ANTICANCER VACCINES TARGETING BORIS AND METHODS OF THEIR APPLICATION |
2018 |
- Yan, Jian
- Slager, Anna
- Garman, Bradley
- Cooch, Neil
|
RU2759681C1 |
| BORIS-TARGETED ANTI-CANCER VACCINES AND METHODS FOR APPLICATION THEREOF |
2018 |
- Yan, Tszyan
- Slager, Anna
- Garman, Bredli
- Kuch, Nil
|
RU2799786C2 |
| METHODS OF TREATING CANCER USING ACTIVATED T-CELLS |
2016 |
- Tang, Longqing
- Tao, Ran
- Liu, Junyun
- Wu, Dongyun
- Han, Yanyan
- Li, Jin
- Zhou, Xiangjun
|
RU2729362C2 |
| METHODS FOR PRODUCING ENRICHED POPULATIONS OF TUMOR-REACTIVE T-CELLS FROM A TUMOR |
2018 |
- Gros Alena
- Rozenberg Stiven A.
|
RU2808817C2 |
| COMBINATION OF SIROSINGOPIN AND MITOCHONDRIAL INHIBITORS FOR TREATMENT OF CANCER AND FOR IMMUNOSUPPRESSION |
2012 |
- Bendzhamin Don
- Kolombi Marko
- Khall Mikhael
- Moroni Kristof
|
RU2602937C2 |
| THERAPEUTIC USE OF THE TLR AGONIST AND COMBINED THERAPY |
2011 |
- Khershberg Robert
- Kukos Dzhordzh
- Ditsh Gregori
- Fachchjabene Andrea
- Mandzharrez Kristi
- Rendall Tressa D.
|
RU2603467C2 |
