FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of formula (I) or (II) or its pharmacologically acceptable salt, solvate or hydrate, where R1 is 1-ethyl-2-methyl-4-imidazolyl, 4-(N-methylaminocarbonyl)-phenyl, 2,2-difluoroethyl; R2 is a 4-(N,N-dimethylamino)sulfonyl)phenyl, 2-(methylsulfonyl)ethyl, 4-(N-methylaminocarbonyl)phenyl. The invention also relates to the use of a compound of formula (I) or (II), a pharmaceutical composition based on a compound of formula (I) or (II), a method for reducing aldosterone levels and a method for the treatment and/or prevention of a disease mediated by CYP11B2 activity based on the use of a compound of formula (I) or (II).
EFFECT: inhibition of the activity of human cytochrome 11B2 (CYP11B2) by a compound of formula (I) or (II).
16 cl, 2 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMAN ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS | 2023 |
|
RU2824362C1 |
| HUMAN CYTOCHROME 11B2 INHIBITORS | 2022 |
|
RU2800378C1 |
| HUMAN ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS | 2022 |
|
RU2811745C1 |
| HUMAN CYTOCHROME 11B2 INHIBITORS | 2021 |
|
RU2783521C1 |
| NOVEL 3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONES AND 2,3-DIHYDRO-ISOINDOLE-1-ONES | 2014 |
|
RU2689421C2 |
| ALDOSTERONE SYNTHASE INHIBITORS BASED ON 2-AMINO-4H-PYRAN-3-CARBONITRILE DERIVATIVES | 2019 |
|
RU2717310C1 |
| NOVEL COMPOUNDS 3,4-DIHYDRO-2N-ISOQUINOLIN-1-ONE AND 2,3-DIHYDROISOINDOL-1-ONE | 2014 |
|
RU2693698C2 |
| 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE DERIVATIVES USEFUL AS ALDOSTERONE SYNTHASE INHIBITOR | 2014 |
|
RU2695524C2 |
| COMBINATION CONTAINING A COMPOUND OF ANGIOTENSIN II-ANTAGONISTIC ACTIVITY | 1997 |
|
RU2188013C2 |
| SYNTHESIS AND USE OF TETRAHYDROPYROLLO[3,2-c]PYRIDIN-4-ONE DERIVATIVES TO TREAT OBESITY, PSYCHIATRIC AND NEUROLOGICAL DISORDERS | 2006 |
|
RU2415856C2 |
