HUMAN ALDOSTERONE SYNTHASE (CYP11B2) INHIBITORS Russian patent published in 2024 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/4427 A61K31/496 A61K31/497 A61K31/501 A61K31/506 A61P9/00 A61P9/04 A61P9/10 A61P9/12 A61P1/16 A61P3/12 A61P13/12 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry, pharmacology and medicine and includes a compound of formula (I), pharmaceutically acceptable salts thereof, a pharmaceutical composition containing it, use, a method for reducing the level of aldosterone and a method of treating. In formula (I) Q₁, Q₂, Q₃, Q₄ is selected independently and represents CH or N; if R₁ is hydrogen, then R₂ is 6-member heterocyclyl containing 2 nitrogen atoms, necessarily substituted with an oxo group, or -(C1-C3)-alkyl-(C3-C6)-cycloalkyl, as well as optionally substituted with 1 substituent selected from (C1-C5)-alkyl; if R₁ is -C(=O)-NH-(C1-C5)-alkyl, then R₂ is NRcRd, where Rc and Rd together with the nitrogen atom to which they are attached form 8-membered bicyclic heterocyclyl containing 1-2 nitrogen atoms, optionally substituted with 1 substitute selected from (C1-C5) -alkyl.

EFFECT: compound of formula (I) for inhibiting human cytochrome P450 11B2 (CYP11B2) activity and use in treating and/or preventing diseases and disorders which are mediated or supported by the activity of the hormone aldosterone.

14 cl, 2 tbl, 3 ex