FIELD: biotechnology.
SUBSTANCE: invention presents a nucleic acid containing a sequence encoding human TREM2, characterized in that human TREM2 contains a mutant stem region containing an amino acid sequence selected from any of SEQ ID NO: 33-40 which confers resistance to sheddase cleavage. The invention also relates to a method for treating a TREM2 related disease or disorder in a subject in need thereof. The method includes administering to a subject in need of treatment a presented nucleic acid.
EFFECT: invention makes it possible to increase the effectiveness of treatment of a disease or disorder associated with TREM2 in a subject.
34 cl, 8 dwg, 4 tbl, 8 ex
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