FIELD: pharmaceutical industry.
SUBSTANCE: invention provides a mutant aminoacyl-tRNA synthetase having a deletion mutation in the corresponding amino acid sequence of the wild-type aminoacyl-tRNA synthetase: 102nd, 128–140th and 159–179th amino acid residues.
EFFECT: obtaining mutant lysyl-tRNA synthetase that compared with wild-type lysyl-tRNA synthetase has high activity, high expression level and good solubility, and can significantly increase the number of non-natural amino acid insertions and the expression level of the target protein containing no naturally occurring amino acid.
11 cl, 5 dwg, 3 tbl, 4 ex
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