Patenton — panteon of patents

(19)

RU

(11)

2 816 654

(13)

C2

(51)

IPC

C12P21/00(2006-01-01)

C12N9/10(2006-01-01)

C12N9/88(2006-01-01)

C12N1/21(2006-01-01)

C12N15/70(2006-01-01)

C07K14/62(2006-01-01)

C12R1/19(2006-01-01)

(21) (22)

Application

2021121175, 2019-12-10

(24)

Start date

2019-12-10

(22)

Actual filing date

2019-12-10

(45)

Published

2024-04-02

(72)

Inventor

Hauptmann, PeterCorcoles Garcia, AngelLattemann, Claus TobiasMatzen, ArneNeubauer, Peter

(73)

Holder

Sanofi-Aventis Deutschland GmbhTechnische Universitaet Berlin

METHOD FOR REDUCING ERRONEOUS INCLUSION OF NON-CANONICAL BRANCHED-CHAIN AMINO ACIDS Russian patent published in 2024 - IPC C12P21/00 C12N9/10 C12N9/88 C12N1/21 C12N15/70 C07K14/62 C12R1/19 

Abstract RU 2816654 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to recombinant production of polypeptides and can be used to produce polypeptides of interest in microbial host cells. Invention is aimed at increasing the activity of acetohydroxy acid synthase (AHAS) (EC 2.2.1.6) when producing a polypeptide of interest, in a microbial host cell containing a recombinant polynucleotide coding said polypeptide compared to AHAS activity in an unmodified microbial host cell.

EFFECT: invention reduces the level of erroneous inclusion of non-canonical branched-chain amino acids (ncBCAA), namely norvaline and / or norleucine, into a recombinant polypeptide of interest and produced in a modified microbial host cell.

35 cl, 12 dwg, 10 ex, 12 tbl

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RU 2 816 654 C2

Authors

Hauptmann, Peter

Corcoles Garcia, Angel

Lattemann, Claus Tobias

Matzen, Arne

Neubauer, Peter

Dates

2024-04-02—Published

2019-12-10—Filed

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