ANTIBODIES TO ENTPD2, TYPES OF COMBINATION THERAPY AND METHODS FOR USING ANTIBODIES AND TYPES OF COMBINATION THERAPY Russian patent published in 2023 - IPC C07K16/28 C07K16/30 C07K16/40 A61K39/395 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. An antibody or its antigen-binding fragment has been proposed that specifically binds to the human ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) protein. A nucleic acid encoding the specified antibody or its antigen-binding fragment, an expression vector containing the specified nucleic acid, a cell containing a nucleic acid or an expression vector are also proposed. A pharmaceutical composition for the treatment of cancer characterized by overexpression of ENTPD2, containing an antibody or its antigen-binding fragment, nucleic acid, vector or cell, has also been proposed. A method for the treatment of cancer characterized by overexpression of ENTPD2 in a subject and a method for stimulating the immune response in a subject are also proposed, providing for the administration of the specified antibody or antigen-binding fragment, nucleic acid, vector, cell or pharmaceutical composition to the subject.

EFFECT: invention can be used in the therapy of cancer characterized by overexpression of ENTPD2.

39 cl, 17 dwg, 30 tbl, 14 ex