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2 809 160

(13)

C2

(51)

IPC

A61K35/17(2015-01-01)

A61P35/00(2006-01-01)

A61P35/02(2006-01-01)

(21) (22)

Application

2019105559, 2017-07-28

(24)

Start date

2017-07-28

(22)

Actual filing date

2017-07-28

(45)

Published

2023-12-07

(72)

Inventor

Anak, OzlemBajlik, SejnelaBrogdon, DzhenniferKemeron, Dzhon, SkottChou, UillyamKhauard, Denni, Roland, Ml.Isaaks, RandiDzhun, Karl, Kh.Lejsi, SajmonMod, ShennonMilenkhorst, Yan, Dzh.Shaster, StivenKintas-Kardama, AlfonsoGrapp, StefanBitter, Khans

(73)

Holder

Novartis AgDze Trastiz Of Dze Yuniversiti Of Pensilvaniya

TYPES OF COMBINATION THERAPY USING CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS Russian patent published in 2023 - IPC A61K35/17 A61P35/00 A61P35/02 

Abstract RU 2809160 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the use of a chimeric antigen receptor (CAR) therapy for CD19, containing a population of immune effector cells expressing CAR for CD19, for the treatment of cancer in a subject in combination with a PD–1 inhibitor. Also a method of treating a subject having cancer, comprising administering to the subject a CD19 CAR therapy and a PD-1 inhibitor is disclosed.

EFFECT: invention is effective for the treatment of cancer.

95 cl, 14 dwg, 8 tbl, 16 ex

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RU 2 809 160 C2

Authors

Anak, Ozlem

Bajlik, Sejnela

Brogdon, Dzhennifer

Kemeron, Dzhon, Skott

Chou, Uillyam

Khauard, Denni, Roland, Ml.

Isaaks, Randi

Dzhun, Karl, Kh.

Lejsi, Sajmon

Mod, Shennon

Milenkhorst, Yan, Dzh.

Shaster, Stiven

Kintas-Kardama, Alfonso

Grapp, Stefan

Bitter, Khans

Dates

2023-12-07—Published

2017-07-28—Filed

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