FIELD: pharmaceutical chemistry.
SUBSTANCE: compound 1-bromo-3-(2,3-dimethylphenyl)butan-2-one is presented for the preparation of medetomidine and its derivatives of the structural formula 5. In another embodiment, a method is provided for synthesizing compound 5 to obtain medetomidine and its derivatives, a method for producing medetomidine as a copper (I) complex of formula 3, methods for producing medetomidine of formula 2, a method for producing medetomidine derivative 4-[1-(2,3-dimethylphenyl) ethyl]-1,3-dihydro-2H-imidazole-2-thione of formula 24.
EFFECT: group of inventions provides new synthetic ways of obtaining medetomidine, which are safer and rather cheap when introduced into industrial production. In addition, the advantages of the developed synthetic route are the wide possibilities to modify the molecule of the final product, medetomidine, and obtain various derivatives with biological activity.
8 cl
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