FIELD: pharmaceutical chemistry.
SUBSTANCE: invention describes a method of producing dexmedetomidine and its pharmaceutically acceptable salts. Technical problem solved by the invention consists in the development of the most waste-free and cheap method for synthesis of dexmedetomidine. Result is achieved due to preliminary enrichment of medetomidine with S-enantiomer at early stages of synthesis, by effective method of regeneration of “chiral wastes”, as well as separating amine.
EFFECT: higher efficiency due to increased degree of dexmedetomidine extraction from racemic mixture.
3 cl, 2 dwg, 2 tbl, 1 ex
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