FIELD: medicine.
SUBSTANCE: it is proposed to use an agent for inhibiting the uptake of amino acids by naive T-cells in the peripheral blood of a mammal for the production of a drug for the treatment of Alzheimer's disease in an individual, where the amino acid is one or more selected from the following: 4-OH proline, acetylornithine, alanine, alpha-aminoadipic acid, asparagine, aspartic acid, asymmetric dimethylarginine, beta-alanine, carnosine, citrulline, creatinine, GABA, glutamic acid, glutamine, glycine, histidine, hypotaurine, isoleucine, kynurenine, leucine, lysine, methionine, methionine sulfoxide, ornithine, phenylalanine, pipecolic acid, proline, putrescine, pyroglutamic acid, serine, serotonin, taurine, threonine, tryptophan, tyrosine and valine. Also provided are methods of treating Alzheimer's disease, comprising administering an agent for inhibiting amino acid uptake by naive T cells in the peripheral blood of a mammal to a patient.
EFFECT: treatment of Alzheimer's disease by inhibiting neuroinflammation.
9 cl, 23 dwg, 4 tbl, 4 ex
