FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions can be used for the treatment and/or prevention of Alzheimer's disease. The following is proposed: the use of an agent for regulating the relative abundance of intestinal microbes for the production of a medicinal product for the treatment of Alzheimer's disease in an individual, wherein the intestinal microbes are selected from one or more of the following: Firmicutes, Bacteroidetes, Proteobacteria, Actinomycetes, Fusobacteria, Cyanobacteria, Verrucomicrobia, or a combination thereof, and where the agent makes the relative abundance of intestinal microbes in an individual close to or approaching the relative abundance of the corresponding intestinal microbes in a corresponding normal individual. Also the following is provided: a method of screening a drug candidate that can be used to treat Alzheimer's disease, a method of creating an animal model for Alzheimer's disease, and a method of treating a patient having Alzheimer's disease.
EFFECT: group of inventions provides a new strategy for the treatment of Alzheimer's disease by interfering with the brain-gut axis.
9 cl, 23 dwg, 4 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF IDENTIFYING PATIENT SENSITIVE TO MEDICINAL PRODUCT BASED ON MANNURONIC ACID OLIGOSACCHARIDES AMONG PATIENTS WITH ALZHEIMER'S DISEASE | 2020 |
|
RU2806017C2 |
| METHOD FOR TREATMENT OF ALZHEIMER'S DISEASE BY T-CELL INHIBITION OF AMINO ACID UPTAKE | 2020 |
|
RU2791665C1 |
| METHOD OF TREATMENT OF ALZHEIMER'S DISEASE THROUGH REGULATION OF AMINO ACID LEVEL | 2020 |
|
RU2801150C1 |
| REDUCED LEVELS OR ACTIVITY OF SYSTEMIC REGULATORY T CELLS FOR TREATING DISEASE OR CNS INJURY | 2015 |
|
RU2690670C2 |
| REDUCED SYSTEMIC LEVELS OR ACTIVITY OF REGULATORY T-CELLS FOR TREATING DISEASE AND CENTRAL NERVOUS SYSTEM INVOLVEMENT | 2017 |
|
RU2815892C1 |
| COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DISTURBANCES | 2005 |
|
RU2387453C2 |
| PEPTIDE COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE | 2021 |
|
RU2816119C1 |
| METHOD OF REDUCING AMYLOID DEPOSITION, AMYLOID NEUROTOXICITY AND MICROGLYOSIS BY (-)-ENANTIOMER NILVADIPINE | 2008 |
|
RU2490014C2 |
| REDUCED SYSTEMIC LEVEL OF REGULATORY T-CELLS OR THEIR ACTIVITY FOR TREATING CNS DISEASES AND TRAUMAS | 2016 |
|
RU2741366C2 |
| ALPHA-V BETA-8-BINDING ANTIBODIES | 2012 |
|
RU2614252C2 |
