FIELD: biotechnology.
SUBSTANCE: group of inventions including a bispecific antibody and a method for its production is described. The bispecific antibody comprises a first antigen-binding fragment that specifically binds to an epitope in the RBD receptor-binding domain of SARS-COV2 SARS-COV2 spike protein S and a second antigen-binding fragment that specifically binds to human CD3, the said antibody comprising the amino acid sequence of SEQ ID NO: 1.
EFFECT: invention expands the arsenal of agents that specifically bind to an epitope in the RBD receptor-binding domain of the SARS-COV2 SARS-COV2 spike protein S and specifically bind to human CD3.
8 cl, 7 dwg, 1 tbl, 3 ex
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METHOD FOR DETERMINING THE ACTIVITY OF NEUTRALISING ANTIBODIES AGAINST SARS-CoV-2 IN THE SERUM OR PLASMA OF PEOPLE WITH PAST CASES OF COVID-19 OR VACCINATED WITH PREVENTIVE VACCINES AGAINST THE NOVEL CORONAVIRUS INFECTION COVID-19 USING A SET OF ENZYME IMMUNOASSAY REAGENTS CONTAINING A RECOMBINANT RECEPTOR-BINDING DOMAIN (RBD) OF SURFACE GLYCOPROTEIN S OF CORONAVIRUS SARS-CoV-2 AND RECOMBINANT HUMAN RECEPTOR ACE2 | 2021 |
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RU2773397C1 |
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Authors
Dates
2023-03-13—Published
2022-06-17—Filed