NEW HETEROCYCLIC DERIVATIVE Russian patent published in 2023 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/4985 A61K31/519 A61K8/49 A61K8/55 A61P17/14 A61Q7/00 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions includes a compound with formula 1, specific compounds indicated in the claims, as well as pharmaceutical and cosmetic compositions based thereon. In Formula 1, R₁, R₂ and R₃ are each independently hydrogen, alkyl, cycloalkyl, halogen, hydroxy, carboxyl, amino, cyano, alkyl alkoxyphosphate, -NR₆ R₇, -CH₂ NR₈ R₉, -N=NR₄₂, aryl, alkylcarbonyl, alkylarylcarbonyl, alkoxycarbonyl, haloalkyl, cycloalkoxy, heterocycloalkyl, alkylaryl, arylalkyl; R₄ is alkyl, cycloalkyl, halogen, hydroxy, carboxyl, amino, alkylalkoxyphosphate, -NR₆ R₇, -CH₂ NR₈ R₉, -N=NR₄₂, aryl, alkylcarbonyl, alkylarylcarbonyl, alkoxycarbonyl, haloalkyl, cycloalkoxy, heterocycloalkyl, alkylaryl, arylalkyl; where said alkyl or alkoxy group contains 1-6 carbon atoms, cycloalkyl is C₃-C₁₀ cycloalkyl, aryl is C₆-C₂₀ aryl, and heteroaryl, heterocycloalkyl are monovalent radicals containing 6 ring atoms and 1 a heteroatom selected from oxygen or nitrogen; R₅ is selected from the group consisting of formulas 2, 3 and 4 of the claims, or R₅ is a polycyclic functional group selected from spiro[4.5]decanil, 4,5,6,7-tetrahydropyrazolo[1,5 -a]pyridinyl, 1,2,3,5,6,7-hexahydro-s-indacenyl or norbornanyl; X₁ and X ₂ are each independently nitrogen (N) or carbon (C), provided that at least one carbon atom (C) is present; is a single bond or a double bond; L represents -NH- or -CH ₂ NH-.

EFFECT: derivatives of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-d]pyrimidine and pyrazolo[3,4-b]pyrazine, which have the properties of a proliferation promoter of dermal ridge cells and are used to prevent or treat hair loss.

11 cl, 1 dwg, 1 tbl, 123 ex

formula 1