6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND USE THEREOF AS NEGATIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS Russian patent published in 2019 - IPC C07D487/04 A61K31/4985 A61P25/00

Abstract RU 2696135 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), where R¹ is phenyl substituted with one or more substitutes, each of which is independently selected from a group consisting of halogen, C_1-4alkyl, polyhalogen-C_1-4alkyl; R² is C_1-4alkyl, aryl or Het; where aryl is phenyl; Het is selected from a group consisting of pyridinyl, pyrazinyl, each of which is optionally substituted with one substitute selected independently from a group consisting of halogen, C_1-4alkyl, -NR^6aR^6b; each of R^6a and R^6b independently represents hydrogen or C_1-4alkyl; R³ is hydrogen; R⁴ is C_1-4alkyl; or a pharmaceutically acceptable salt thereof.

(I).

EFFECT: compounds of the invention are intended for preventing or treating disorders involving metabotropic receptors of mGluR2 subtype.

9 cl, 7 tbl, 3 ex

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RU 2 696 135 C2

Authors

Conde-Ceide, Susana

Van Gool, Michiel, Luc, Maria

Martin-Martin, Maria Luz

Dates

2019-07-31—Published

2015-07-30—Filed