LIPID-BASED OPHTHALMIC EMULSION Russian patent published in 2023 - IPC A61K9/107 A61K31/736 A61K47/10 A61K47/12 A61K47/24 A61K47/26 A61P27/02 

FIELD: medicine.

SUBSTANCE: invention relates to ophthalmology, and to an ophthalmic emulsion containing a gelatinized polymeric hydroxypropyl guar and anionic lipids to provide improved protection against drying and moisture retention. The ophthalmic emulsion contains water, oil, a hydrophilic surfactant and a hydrophobic surfactant, a charged phospholipid, a borate, a mucoadhesive galactomannan polymer, and a preservative. The mucoadhesive galactomannan polymer is present in the emulsion in an amount of at least 0.12 w/v% but not more than 0.4 w/v%. The preservative is free from benzalkonium chloride. The emulsion contains oil droplets dispersed in water and the droplet size D₉₀ is less than 700 nm but greater than 10 nm. The emulsion is characterized by a level of hydration protection against drying, which is at least 10% higher than that of the reference emulsion, while the control emulsion has the same composition as the ophthalmic emulsion, except that it contains 0.05 w/v% of the same galactomannan polymer as that used in the ophthalmic emulsion.

EFFECT: reduction of blurred vision during instillation and improvement of hydration protection of the eyes from drying out and hydration of the eye surface.

15 cl, 3 dwg, 2 tbl