FIELD: biotechnology.
SUBSTANCE: antibody specifically linking with claudin 18A2 is proposed. Immunoconjugates including the said antibody, a chimeric antigenic receptor to detect claudin 18A2, an immune cell modified with a chimeric antigenic receptor that are used for preparation of antitumoral medical remedies and reagents for diagnostics of tumors expressing claudin 18A2 are also proposed. Moreover, nucleic acids for production of antibodies, immunoconjugates and chimeric antigenic receptors are disclosed.
EFFECT: increased cytotoxic activity in relation to cells expressing claudin 18A2.
35 cl, 27 dwg, 7 tbl, 15 ex
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