FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, particularly to a chimeric antigen receptor. Said chimeric antigen receptor specifically recognizes ganglioside GD2 and contains a GD2-binding domain containing CDR1-CDR3 of the heavy chain with sequences SEQ ID NO: 1–3, respectively, as well as light chain CDR1-CDR3 with sequences SEQ ID NO: 9–11, respectively. Present invention also relates to a polynucleotide coding said chimeric antigen receptor, a cell, including a T-cell or NK-cell containing said polynucleotide, as well as a pharmaceutical composition containing an effective amount of T-cells or NK-cells.
EFFECT: invention provides high cytotoxic activity and therapeutic efficacy in treating cancer, which is aimed at GD2 at the molecular level.
9 cl, 27 dwg, 18 ex
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