CHIMERIC ANTIGENIC RECEPTORS TO CD22 Russian patent published in 2018 - IPC C07K14/705 C07K19/00 C12N15/117 C12N15/63 C12N5/783 A61K38/57 A61K39/00 A61K48/00 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to a chimeric antigenic receptor (CAR) with a specificity for CD22, which can be used in medicine. The CAR receptor containing an HA22 antigen-binding domain, a transmembrane domain and an intracellular signal T cell domain, as well as the nucleic acid encoding the claimed receptor, a recombinant expression vector containing the said nucleic acid, a population of isolated host cells for expression of the resulting receptor, a pharmaceutical composition comprising the resulting receptor, methods for treatment and detection of CD22-expressing cancer and methods for application of the resulting receptor for production of a medicament for CD22-expressing cancer treatment.

EFFECT: invention allows effective control of CD22-expressing cancer by activation of the lysis of the said cells by the resulting chimeric receptor.

15 cl, 9 dwg, 2 tbl, 8 ex