METHOD FOR THE TREATMENT AND PREVENTION OF RECURRENCE OF NOSOCOMIAL PNEUMONIA Russian patent published in 2023 - IPC G01N33/48 A61K35/76 A61P11/00 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention relates to anesthesiology and resuscitation, and can be used for the treatment or prevention of recurrence of nosocomial pneumonia (NP) in patients of intensive care units and intensive care units. The base complex of bacteriophages containing phages active against the bacteria of the main pathogens of NP obtained from the biomaterial of patients of this institution is used: Acinetobacter baumannti, Citrobacter freundii, Enterobacter cloacae, Enterobacter kobei, Enterococcus faecium, Klebsiella ozaenae, Klebsiella pneumoniae, Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Stenotrophomonas maltophilia, Streptococcus pyogenes. Then it is adapted to a specific department or medical institution by including bacteriophages in the complex active against each of the 14 types of bacteria listed above detected by spot testing. A ready-made form containing an adapted composition of bacteriophages being an active substance in the form of a mixture of sterile purified bacteriophages at a Grace concentration of 10⁴-9.9x10⁷ PFU/cm³ in 1 ml, an auxiliary substance in the form of a physiological solution up to 5 ml. At the same time, the finished form is administered by inhalation to patients in 1 dose of 5 ml 2–3 times a day for at least 7 days.

EFFECT: invention provides a significant reduction in the frequency of NP relapses in the most severe ICU patients who are in critical condition and need replacement of vital functions.

2 cl, 2 ex