FIELD: medicine; biotechnology.
SUBSTANCE: proposed bactericidal pharmaceutical composition, including, wt.%: recombinant modified endolysin LysECD7-SMAP — 0.1–0.5%, poloxamer 188 — 0.01%, phosphate buffer solution pH=7.5 — 99.49–99.89%; and the use of said composition as an antimicrobial agent.
EFFECT: expansion of the arsenal of pharmaceutical compositions with a pronounced specific antibacterial activity against gram-negative bacteria when used systemically, including bacteria with multidrug resistance.
2 cl, 2 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BACTERICIDAL PHARMACEUTICAL COMPOSITION FOR TOPICAL APPLICATION IN THE FORM OF AN ENDOLYSIN-CONTAINING BACTERICIDAL GEL | 2021 |
|
RU2781050C1 |
| MODIFIED ENDOLYSIN AND ANTIBACTERIAL COMPOSITIONS BASED THEREON FOR TREATING INFECTIONS CAUSED BY ACINETOBACTER BAUMANNII, PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI BACTERIA | 2023 |
|
RU2813626C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST GRAM-NEGATIVE BACTERIA: PSEUDOMONAS AERUGINOSA, ACINETOBACTER BAUMANNII, KLEBSIELLA PNEUMONIAE AND SALMONELLA TYPHI (EMBODIMENTS) | 2019 |
|
RU2730615C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST BACTERIA PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI, SALMONELLA TYPHI AND STAPHYLOCOCCUS HAEMOLYTICUS (EMBODIMENTS) | 2019 |
|
RU2730614C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST BACTERIA PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI, SALMONELLA TYPHI AND STAPHYLOCOCCUS HAEMOLYTICUS (EMBODIMENTS) | 2019 |
|
RU2730613C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS AN ANTIMICROBIAL AGENT DIRECTED AGAINST ACINETOBACTER BAUMANNII BACTERIA, (EMBODIMENTS) | 2019 |
|
RU2730616C1 |
| ANTIBACTERIAL COMPOSITION BASED ON ENDOLYSINS AND DRUGS IN FORM OF GEL OR SPRAY, USING IT | 2021 |
|
RU2790481C1 |
| PHARMACEUTICAL COMPOSITION FOR TREATING BACTERIAL INFECTIONS CAUSED BY THE MAIN PATHOGENS | 2023 |
|
RU2825961C1 |
| ANTIBACTERIAL COMPOSITION CONTAINING ADK PROTEIN AS AN ACTIVE INGREDIENT FOR CONTROLLING CARBAPENEM-RESISTANT GRAM NEGATIVE BACTERIA | 2016 |
|
RU2668160C1 |
| BACTERIOPHAGES, PHAGE PEPTIDES AND METHODS FOR APPLICATION THEREOF | 2011 |
|
RU2614114C2 |
