ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST GRAM-NEGATIVE BACTERIA: PSEUDOMONAS AERUGINOSA, ACINETOBACTER BAUMANNII, KLEBSIELLA PNEUMONIAE AND SALMONELLA TYPHI (EMBODIMENTS) Russian patent published in 2020 - IPC C07K14/05 C07K19/00 C12N9/24 C12P21/02 A61K38/47 A61K31/198 A61P31/04 

Abstract RU 2730615 C1

FIELD: biotechnology; medicine.

SUBSTANCE: invention relates to biotechnology, specifically to therapeutic proteins, and can be used in medicine as an antibacterial agent. Disclosed is use of recombinant endolysin bacteriophage, including in combination with pharmaceutically acceptable carriers and/or substances increasing membrane permeability, as an antimicrobial agent directed against gram-negative bacteria: Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae and Salmonella typhi. Antibacterial compositions are obtained based on said protein, including fused with 8-histidine tag.

EFFECT: invention provides effective penetration of endolysin without adding various permeabilisers or covalently bound penetrating peptides through the outer membrane of said bacteria and cleavage of peptidoglycan, which ultimately leads to death of bacteria.

4 cl, 5 dwg, 3 tbl, 6 ex

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RU 2 730 615 C1

Authors

Antonova Nataliia Petrovna

Vasina Daria Vladimirovna

Gintsburg Aleksandr Leonidovich

Tkachuk Artem Petrovich

Gushchin Vladimir Alekseevich

Dates

2020-08-24Published

2019-05-08Filed