FIELD: biotechnology.
SUBSTANCE: composition immunogenic against pneumococcal disease caused by Streptococcus pneumoniae, containing at least one aHD-PRD recombinant construct, consisting of an alpha-helical domain (aHD) and a proline-rich domain (PRD) of pneumococcal surface protein A Streptococcus pneumoniae (PspA), and at least one pharmaceutically acceptable excipient is proposed. Also a vaccine for inducing an immune response against S. pneumonia containing the specified composition, a recombinant nucleic acid molecule that encodes the aHD-PRD construct, an expression vector and a host cell containing such molecules, the use of the specified composition or the specified vaccine to maximize cross-reactivity against pathogenic pneumococci and providing protection against a wide range of pneumococcal strains or serotypes not included in the said composition or the said vaccine are proposed.
EFFECT: invention maximizes cross-reactivity and provides protection against a wide range of pneumococcal serotypes.
12 cl, 9 dwg, 4 tbl, 7 ex
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RU2725950C1 |
