FIELD: medicine; experimental medicine; biology; toxicology.
SUBSTANCE: invention relates to medicine, specifically to experimental medicine, biology, toxicology, and concerns a method for modeling encephalopathy in offspring when exposed to non-toxic doses of manganese in the prenatal period. For that purpose manganese sulphate pentahydrate is added daily to the total ration of female rats at a dose of 1433 mg/kg/day during the pregestational period of 4 weeks and the gestation period of 3 weeks.
EFFECT: invention makes it possible to create a model of encephalopathy in offspring, as close as possible to the etiology and clinic in humans.
1 cl, 4 dwg, 1 tbl, 3 ex
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| DIAGNOSTIC TECHNIQUE FOR MERCURY ENCEPHALOPATHY IN SMALL LABORATORY ANIMALS | 2011 |
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| METHOD OF SIMULATING MNESTATIC ARTICLES | 0 |
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