FIELD: chemistry; pharmaceutics.
SUBSTANCE: present invention provides a compound targeting a prostate-specific membrane antigen (PSMA), or a pharmaceutical salt thereof. Said compound has a structure represented by formula (II-1). Present invention further discloses a method of producing said compound, a radioactive isotope-labelled complex based on the compound of formula (II-1) and a method of producing said compound, as well as a pharmaceutical composition.
EFFECT: said compound and the radioactive isotope-labelled complex are characterized by a corresponding residence time in the bloodstream, a relatively high level of absorption and retention by a tumour and are suitable for use in nuclide therapy and imaging of high-expression PSMA tumours.
7 cl, 15 dwg, 32 ex
Formula (II-1)
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL TUMOR ANTIGEN BINDING AGENTS AND USE THEREOF | 2019 |
|
RU2831681C2 |
| COMPLEX CONTAINING A PSMA-TARGETING COMPOUND BOUND TO A LEAD OR THORIUM RADIONUCLIDE | 2018 |
|
RU2795398C2 |
| NEW PSA-BINDING AGENTS AND THEIR USE | 2018 |
|
RU2787105C2 |
| PSMA-TARGET COMPOUND AND ITS COMPLEX WITH RADIONUCLIDES FOR THERANOSTICS OF TUMOR EXPRESSING PSMA | 2022 |
|
RU2803734C1 |
| LYOPHILISATE BASED ON PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS FOR PREPARING A RADIOPHARMACEUTICAL COMPOSITION IN FORM OF SOLUTION FOR INJECTIONS FOR TREATING PROSTATE CANCER, RADIOPHARMACEUTICAL COMPOSITION BASED ON IT FOR TREATING PROSTATE CANCER AND METHOD FOR PREPARING RADIOPHARMACEUTICAL COMPOSITION | 2023 |
|
RU2817970C1 |
| COMPLEX OF UREA DERIVATIVE WITH Tc RADIONUCLIDE LABEL FOR DIAGNOSIS OF TUMORS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN, AND METHOD FOR PRODUCTION THEREOF | 2023 |
|
RU2825402C1 |
| COMPOUND FOR DIAGNOSING TUMOURS EXPRESSING PSMA AND COMPOSITION BASED THEREON | 2019 |
|
RU2730507C1 |
| METHOD OF OBTAINING PSMA-TARGET COMPOUND COMPLEX BASED ON UREA Lu-PS-161 AND COMPLEX | 2023 |
|
RU2808636C1 |
| RADIOPHARMACEUTICAL FOR THE DIAGNOSIS OF PROSTATE CANCER BY POSITRON EMISSION TOMOGRAPHY AND METHOD FOR ITS PRODUCTION | 2022 |
|
RU2796106C1 |
| RADIOPHARMACEUTICALS, RADIOIMAGING AGENTS AND THEIR USE | 2018 |
|
RU2804297C2 |
