FIELD: organic chemistry.
SUBSTANCE: invention relates to the use of biologically active compounds of the class N,1-diaryl-2-methyl-1,2,3,4-thioxo-1,6-tetrahydropyrimidine-4-carboxamides, namely 4-(2-bromophenyl)-1,2,3,4-methyl-N-(5-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide. The invention relates to the use of 1,6-dimethyl-N-phenyl-4-(4-fluorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide of formula (1):
,
with analgesic activity.
EFFECT: proposed compound exhibits high analgesic activity with low toxicity, which allows it to be used to create an agent with analgesic activity.
1 cl, 2 dwg, 2 tbl, 2 ex
| Title |
Year |
Author |
Number |
| USE OF 4-(4-BROMOPHENYL)-6-METHYL-2-THIOXO-N-(O-TOLYL)-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDE AS AGENT HAVING ANALGESIC ACTIVITY |
2024 |
- Zamaraeva Tatiana Mikhailovna
- Buzmakova Nadezhda Albertovna
- Podchezertseva Karina Vladimirovna
|
RU2835601C1 |
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2022 |
- Gein Vladimir Leonidovich
- Zamaraeva Tatiana Mikhailovna
- Rudakova Irina Pavlovna
|
RU2793550C1 |
| ETHYL 4-(5-BENZOYL-6-(4-(DIETHYLAMINO)PHENYL)-4-HYDROXY-2-THIOXOHEXAHYDROPYRIMIDIN-4-CARBOXAMINO)BENZOATE, EXHIBITING ANALGESIC AND ANTI-INFLAMMATORY ACTION |
2019 |
- Gejn Vladimir Leonidovich
- Gorgopina Ekaterina Vladimirovna
- Zamaraeva Tatyana Mikhajlovna
- Rudakova Irina Pavlovna
- Dozmorova Natalya Viktorovna
|
RU2717246C1 |
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2022 |
- Gein Vladimir Leonidovich
- Zamaraeva Tatiana Mikhailovna
- Rudakova Irina Pavlovna
|
RU2785688C1 |
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2015 |
- Gejn Vladimir Leonidovich
- Zamaraeva Tatyana Mikhajlovna
- Buzmakova Nadezhda Albertovna
- Syropyatov Boris Yakovlevich
- Alikina Nataliya Viktorovna
|
RU2653511C2 |
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2023 |
- Gorgopina Ekaterina Vladimirovna
- Zamaraeva Tatiana Mikhailovna
- Rudakova Irina Pavlovna
- Gein Vladimir Leonidovich
|
RU2811249C1 |
| USE OF METHYL 5-BENZOYL-4-HYDROXY-6-(4-CHLOROPHENYL)-2-THIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE AS AN AGENT HAVING ANALGESIC AND ANTI-INFLAMMATORY ACTION |
2024 |
- Zamaraeva Tatiana Mikhailovna
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- Gorgopina Ekaterina Vladimirovna
|
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| USE OF 4-[1-(4-METHYLPHENYL)AMINOETHYLIDENE]-5-PHENYL-1-CYANOMETHYLTETRAHYDROPYRROLE-2,3-DIONE AS AN ANALGESIC |
2023 |
- Gein Vladimir Leonidovich
- Buldakova Evgeniia Anatolevna
- Gein Oksana Nikolaevna
|
RU2806330C1 |
| APPLICATION OF METHYL 5-BENZOYL-6-(4-FLUOROPHENYL)-4-METHOXY-2-THIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE AS AN ANTI-INFLAMMATORY AGENT |
2022 |
- Gein Vladimir Leonidovich
- Zamaraeva Tatiana Mikhailovna
- Rudakova Irina Pavlovna
- Gorgopina Ekaterina Vladimirovna
|
RU2786805C1 |
| METHYL 4-HYDROXY-4-METHYL-6-PHENYL-2-CYANOACETYLHYDRAZONOCYCLOHEXANE-1-CARBOXYLATE EXHIBITING ANALGESIC ACTIVITY |
2010 |
- Vagapov Aleksej Vladimirovich
- Nosova Natal'Ja Vladimirovna
- Gejn Vladimir Leonidovich
- Syropjatov Boris Jakovlevich
- Vakhrin Mikhail Ivanovich
- Danilova Natalija Vladimirovna
|
RU2446150C2 |
