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2 797 123

(13)

(51)

IPC

C07D237/04(2006-01-01)

C07D237/20(2006-01-01)

C07D403/04(2006-01-01)

A61K31/501(2006-01-01)

A61P25/28(2006-01-01)

(21) (22)

Application

2020124599, 2018-12-26

(24)

Start date

2018-12-26

(22)

Actual filing date

2018-12-26

(45)

Published

2023-05-31

(72)

Inventor

Li, Richard, E.Tangallapalli, Radzhendra, P.Rok, Charlz, O.Yakovski, SyuzanEdvardz, Enn, V.Yun, Mi, KyujnSubramanian, ChitraZamboni, RobertReddi, T.

(73)

Holder

St. Dzhud Children'Z Riserch Khospital, Ink.Siouej Terapyutiks, Ink.

LOW-MOLECULAR MODULATORS OF PANTOTHENAKINASES Russian patent published in 2023 - IPC C07D237/04 C07D237/20 C07D403/04 A61K31/501 A61P25/28

Abstract RU 2797123 C2

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to new compounds having the structure represented by the following formula

where Q² is a structure selected from the following:

where each of R^3a, R^3b and R^3c independently represents a hydrogen atom or halogen, provided that at least one of R^3a, R^3b and R^3c represents a halogen; and where R⁴ is halogen or -CN.

EFFECT: novel compounds have been obtained that modulate the activity of pantothenate kinase (PanK), which may be suitable for the treatment of metabolic disorders, where the said disorder is hyperglycemia caused by dysregulation and/or increased levels of coenzyme A; or neurodegeneration caused by pantothenate kinase or coenzyme A deficiency.

32 cl, 1 tbl, 10 ex

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RU 2 797 123 C2

Authors

Li, Richard, E.

Tangallapalli, Radzhendra, P.

Rok, Charlz, O.

Yakovski, Syuzan

Edvardz, Enn, V.

Yun, Mi, Kyujn

Subramanian, Chitra

Zamboni, Robert

Reddi, T.

Dates

2023-05-31—Published

2018-12-26—Filed