NOVEL IMIDAZOLIDINE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Russian patent published in 2013 - IPC C07D233/60 C07D233/66 A61K31/4166 A61P5/24 A61P35/00 A61P19/10 

FIELD: chemistry.

SUBSTANCE: present invention relates to organic chemistry and specifically to novel 2,5-dioxo-imidazolidine derivatives of general formula lb , or pharmaceutically acceptable salts and solvates thereof, or solvates of pharmaceutically acceptable salts, where X denotes O; R¹ is H; or R¹ is selected from C₁-C₆ alkyl and C₁-C₆ alkynyl, where the alkyl can optionally be substituted with a cyano group; R^2a is selected from H, P(O)(OH)₂ and C(O)(CH₂)_n1C(O)OH; or R^2a is selected from -C(O)-C₁-C₆ alkyl, which is substituted with amino; n1 equals 1 or 2; each R² and R^c is independently selected from H and C₁-C₆ alkyl; R^3a is H, a halogen atom or cyano; each R^3b is independently a halogen atom or cyano; or each R^3b is independently C₁-C₆ alkyl, optionally substituted with three halogen atoms; each R^4a and R^4b is independently H or a halogen atom; or each R^4a and R^4b is selected from C₁-C₆ alkyl, and C₁-C₆ alkoxy, where the alkyl is substituted with three halogen atoms; R^4c is a halogen atom or cyano; and ml equals 0 or 1. The invention also relates to a pharmaceutical composition based on a compound of formula lb and use thereof.

EFFECT: obtaining novel 2,5-dioxo-imidazolidine derivative which modulate androgen receptor activity.

20 cl, 5 tbl, 31 ex