FIELD: biotechnology.
SUBSTANCE: invention relates to recombinant production of fusion proteins based on Growth/Differentiation Factor 15 (GDF15) and can be used in medicine to reduce body weight, control diet and prevent or treat a metabolic disease. A fusion polypeptide was constructed comprising GDF15 or a functional deleted variant thereof, to the N-terminus of which one strand of the human IgG4 Fc region was attached via a flexible peptide linker.
EFFECT: invention makes it possible to obtain a fusion polypeptide with an extended period of existence of GDF15 in vivo.
19 cl, 11 dwg, 13 tbl, 3 ex
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