FIELD: biotechnology.
SUBSTANCE: invention relates to new pharmaceutical compositions. The invention discloses a composition containing variants of an IL-18 activity enhancer that ensures the activity of the IL-18 signaling pathway even in the presence of an inhibitory molecule such as IL-18BP.
EFFECT: invention can be applied in the immunotherapy of various types of cancer, including those resistant to inhibitors of immune checkpoints.
21 cl, 30 dwg, 12 tbl, 6 ex
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