AGENTS FOR THE TREATMENT OF CLAUDINE-EXPRESSING CANCER DISEASES Russian patent published in 2023 - IPC C07K16/28 C07K16/46 C12N5/10 C12N15/13 C12N15/63 A61K39/395 A61P35/00 

Abstract RU 2798990 C2

FIELD: biotechnology.

SUBSTANCE: group of inventions including a bispecific agent that binds claudin 6 (CLDN6) and CD3, a recombinant nucleic acid, a host cell for the expression of a bispecific agent, the use of a bispecific agent, a recombinant nucleic acid or a host cell for the manufacture of a pharmaceutical composition for the treatment or prevention of cancer, characterized by cancer cells expressing CLDN6, a pharmaceutical composition for treating or preventing cancer characterized by cancer cells expressing CLDN6 and a method for treating or preventing a cancer characterized by cancer cells expressing CLDN6 are described.

EFFECT: invention expands the arsenal of agents binding to claudin 6 (CLDN6) and CD3.

21 cl, 54 dwg, 12 tbl, 34 ex

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RU 2 798 990 C2

Authors

Sakhin, Ugur

Tyurechi, Ezlem

Shtadler Kristiane

Kholland, Yuliya

Ber-Makhmud, Khayat

Bajssert, Tim

Plyum, Laura

Le Gol, Fabris

Jendretski, Arne

Fidler, Markus

Dates

2023-06-30Published

2013-11-12Filed