FIELD: chemistry.
SUBSTANCE: invention relates to a hexapeptide derivative of the formula PG-Met-Asp(OtBu)-Gly-Cys(Trt)-Glu(OtBu)-Leu-OR, where R is selected from C1-C6alkyl such as methyl or tert-butyl, and PG is Fmoc, the process of its production, and the process of the production of Foxy-5 (SEQ ID NO 1) using the said hexapeptide derivative in a linear liquid phase pathway, providing ease of purification of process intermediates, ease of assembly of fragments, high chiral purity, and adaptability to commercial scale.
EFFECT: obtaining linear liquid pathways for WNT hexapeptides.
12 cl, 5 dwg, 1 tbl, 6 ex
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