FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely to method of treatment or prevention of opioid-induced constipation or opioid-induced intestine dysfunction in patients without reduction of mediated opioid anaesthesia or development of symptoms of central opioid withdrawal, associated with activation of opioid receptors on periphery. For this purpose effective quantity of 5-(2-methoxy-4-{[2-(tetrahydropyran-4-yl)-ethylamino]methyl}-phenoxy)pyrazine-2-carboxamide (Compound I) or its pharmaceutically acceptable salt is introduced to patient.
EFFECT: group of inventions provides treatment or prevention of frequent side effects in patients who have taken opioids for several days.
12 cl, 9 dwg, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS FOR PRODUCING AND USING THEM |
2012 |
- Mikl Trevis
- Gjunter Sven
- Chi Gochehn'
- Kan'Ski Jaroslav
- Martin Andrea K.
- Bera Bindu
|
RU2573388C2 |
| ORGANIC COMPOUNDS |
2018 |
- Li, Peng
- Yao, Wei
- Davis, Robert
- Mates, Sharon
- Vanover, Kimberly
- Snyder, Gretchen
|
RU2780002C2 |
| ORGANIC COMPOUNDS |
2018 |
- Li, Peng
- Zheng, Hailin
- Davis, Robert
- Mates, Sharon
- Vanover, Kimberly
- Snyder, Gretchen
|
RU2777366C2 |
| CONJUGATES OF HYDROCODONE WITH BENZOIC ACID, DERIVATIVES OF BENZOIC ACID AND HETERO-ACRYL-CARBON ACID, PRODRUGS, METHODS FOR THEIR OBTAINING AND APPLICATION |
2010 |
- Mikl Trevis
- Gjunter Sven
- Mikl Kristehl
- Chi Gochehn'
- Kan'Ski Jaroslav
- Martin Andrea K.
- Bera Bindu
|
RU2505541C2 |
| APPLICATION OF METHYL NALTREXONE FOR TREATING IRRITABLE COLON SYNDROME |
2004 |
- Bojd Tomas A.
- Izraehl Robert Dzh.
- Sangkhvi Suketu P.
|
RU2373936C2 |
| THERAPEUTIC ANALGESIC |
2009 |
- Josinaga Kodzi
- Khamano Khiroki
- Khorii Takajuki
|
RU2486900C2 |
| BENZOIC ACID, BENZOIC ACID DERIVATIVES AND CONJUGATES OF HETEROARYL CARBOXYLIC ACID AND OXYMORPHONE, PRODRUGS, METHODS FOR OBTAINING AND USE THEREOF |
2015 |
- Martin, Andrea
- Kanski, Jaroslaw
- Bera, Sanjib
- Guenther, Sven
- Mickle, Travis
|
RU2683274C2 |
| COMPOSITIONS AND METHODS OF TREATING OPIOID OVERDOSE |
2017 |
- Crystal, Roger
- Maggio, Edward T.
|
RU2769397C2 |
| USE OF OPIOID RECEPTOR ANTAGONIST WITH K-ACTIVITY AND VORTIOXETINE FOR TREATMENT OF DEPRESSIVE DISORDER WITH MELANCHOLIC FEATURES |
2014 |
- Morillo Connie Sanchez
- Smagin Gennady N.
|
RU2679661C1 |
| METHOD FOR PREVENTION ABUSE WITH OPIOID- -CONTAINING MEDICINAL FORMULATIONS |
1998 |
|
RU2228180C2 |
