METHOD OF QUANTITATIVE DETERMINATION OF ALUMINUM IONS BY ATOMIC ABSORPTION SPECTROMETRY WITH ELECTROTHERMAL ATOMIZATION Russian patent published in 2023 - IPC G01N21/74 

FIELD: analytical chemistry; medicine; pharmacy; biotechnology.

SUBSTANCE: method of quantitative determination of aluminum ions contained in an adjuvant for immunobiological medicinal products (IMP) includes the use of atomic absorption spectrometry with electrothermal atomization, where sample preparation is carried out in at least two stages, where at the first stage sodium hydroxide solution is added to the IMP and to a standard sample of the content of aluminum ions and then it is heated in a boiling water bath until a clear solution of the mixture is obtained, then it is cooled, concentrated nitric acid taken in excess relative to the amount of sodium hydroxide is added, and where at the last stage it is diluted with a solution of 0.1% Trilon X-100 diluted in 0.5% nitric acid to the concentration of the calibration curve, then a quantitative analysis of aluminum ions in the resulting mixture is carried out, if more than two stages of sample preparation are performed, then water is used between the first stage and the last stage.

EFFECT: development of a method for the quantitative determination of aluminum ions in immunobiological medicinal products, which has selectivity, precision and accuracy.

8 cl, 1 dwg, 3 tbl