METHODS OF PREDICTING THE APPLICABILITY OF DISEASE-SPECIFIC AMINO ACID MODIFICATIONS FOR IMMUNOTHERAPY Russian patent published in 2023 - IPC G01N33/68 A61K39/00 A61P35/00 

FIELD: pharmaceuticals; medicine.

SUBSTANCE: objects 1 and 2 are a method for evaluating the applicability of a disease-specific amino acid modification in a peptide or polypeptide expressed in a diseased cell for cancer immunotherapy and a method for selecting and/or ranking disease-specific amino acid modifications based on their applicability in cancer immunotherapy, including determining the presentation of the same or various fragments of a peptide or polypeptide containing a disease-specific amino acid modification in the context of MHC molecules and T-cell reactivity. Object 3 is a method for producing a vaccine, comprising the step of identifying one or more disease-specific amino acid modifications that are predicted by the method to be applicable for cancer immunotherapy.

EFFECT: obtaining personalized vaccines for cancer patients that provide effective targeting of mutanome.

15 cl, 5 dwg, 1 tbl, 6 ex