DETERMINATION OF DOSE FOR IMMUNOTHERAPEUTIC AGENTS Russian patent published in 2022 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the determination of suitable doses of immunotherapeutic agents. The use of a method is disclosed for a contact of immunoreactive material of an individual with an immunotherapeutic agent and measurement of at least one immunological reaction to determine, whether this immunotherapeutic agent is present in a dose suitable for the injection to this individual. The specified immunological reaction is a change in the expression or number of one or more cytokines produced by this immunoreactive material. The dose of an immunotherapeutic agent, at which the immunological reaction indicates the acceptable therapeutic effect, reflects a dose suitable for the injection to an individual, where the acceptable therapeutic agent includes stopping or slowing down the progression of a disease in an individual; inhibiting or slowing down the development of a new disease in an individual; reducing the periodicity or severity of symptoms and/or relapses in an individual and/or increasing the human life expectancy. A method for the determination of a suitable dose of an immunotherapeutic agent for the injection to an individual is also disclosed.

EFFECT: group of inventions provides for the selection of a dose without excessive inconvenience or risks for patients.

38 cl, 13 dwg, 5 tbl, 5 ex