INVARIANT CHAIN CANCER VACCINE FROM TELEOST FISH Russian patent published in 2023 - IPC A61K39/385 

FIELD: biotechnology.

SUBSTANCE: polypeptide having T-cell response enhancing activity is provided, the said polypeptide comprises the following: (a) a Teleostei invariant chain (INV) fragment comprising or consisting of 16 to 27 contiguous membrane proximal domain (MPD) amino acids from Teleostei INV, wherein the fragment has the activity enhancing T-cell response, and the fragment contains an amino acid sequence selected from the following SEQ ID NO: 11 and 4; and one or more cancer-specific antigens or cancer-specific neoantigens and/or one or more antigenic fragments thereof; or (b) a full-size Teleostei INV selected from the following SEQ ID NO: 2 or 9, and one or more cancer-specific antigens or cancer-specific neoantigens and/or one or more antigenic fragments thereof. A polynucleotide encoding the claimed polypeptide is proposed; an expression vector containing the said polynucleotide; a collection of two or more different vectors for preventing or treating a proliferative disease; a pharmaceutical composition for preventing or treating a proliferative disease; a kit for preventing or treating a proliferative disease; the use of a polypeptide, polynucleotide, vector or collection of vectors, or a pharmaceutical composition or kits containing such pharmaceutical compositions, for the prevention or treatment of a proliferative disease.

EFFECT: teleost invariant chain polypeptides or fragments thereof act as “T-cell enhancers” by converting non-immunogenic antigenic sequences into immunogenic T-cell antigens.

17 cl, 1 dwg, 1 tbl, 1 ex