FIELD: biotechnology.
SUBSTANCE: invention concerns a new strain of foot-and-mouth disease virus Aphtae epizooticae of A genotype, Picornaviridae family, Aphthovirus genus, deposited in the All-Russian State Collection of Exotic Types of Foot-and-Mouth Disease Virus and Other Animal Pathogens (GKSM) FGBI "ARRIAH" under registration number No.378 - dep/22-12 — GKShM FGBI "ARRIAH", A/Afghanistan/2017 strain of A genotype of foot-and-mouth disease virus. The presented strain is reproduced in transplanted cell cultures of Siberian mountain ibex kidney (PSGK-30), pig kidney (IB-RS-2), newborn Syrian hamster kidney (VNK-21). In a continuous suspension culture of Syrian hamster kidney cells VNK-21/SUSP/ARRIAN for 18.0–19.5 hours of incubation, the concentration of 146S component of A/Afghanistan/2017 strain of the foot and mouth disease virus reaches values of 1.74±0.08 μg/cm3 (72.44±2.42%), retaining the original characteristics when passaged in cell culture for 10 passages.
EFFECT: presented strain can be used for the manufacture of biopreparations for the diagnostics and specific prevention of FMD of type A and for control of the antigenic activity of FMD vaccines.
1 cl, 1 dwg, 4 tbl, 5 ex
| Title | Year | Author | Number |
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