FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and concerns a strain of foot-and-mouth disease Aphtae epizooticae genotype A/EURO-SA of family Picornaviridae of genus Aphthovirus, deposited in the All-Russian State Collection of Exotic types of foot-and-mouth disease virus and other animal pathogens (FGBI ARRIAH) under registration number No. 482 — dep/23-32 — GKShM FGBU VNIIZZH strain A/Egypt/EURO-SA/2022 genotype A/EURO-SA virus foot-and-mouth disease. Presented strain is reproduced in transplantable cell cultures of Siberian ibex kidney (PSGK-30), porcine kidney (IB-RS-2), newborn Syrian hamster kidney (BHK-21). In a transplantable suspension cell culture of the kidney of the Syrian hamster BHK-21/SUSP/ARRIAH for 10.25±0.59 hours of incubation, concentration of 146S particles of the strain A/Egypt/EURO-SA/2022 of foot-and-mouth disease virus has average values of 2.39±0.09 mcg/cm3 (71.15±0.96%), preserving initial characteristics when passaging in cell culture BHK-21/SUSP/ARRIAH.
EFFECT: presented strain can be used to produce biopreparations for diagnosis and specific prevention of FMD genotype A/EURO-SA and to control antigenic activity of FMD vaccines.
1 cl, 2 dwg, 5 tbl, 7 ex
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