FIELD: biochemistry.
SUBSTANCE: invention relates to an antibody that binds to BCMA. Also a nucleic acid encoding the said antibody; a vector and a host cell expressing the said antibody; immunoconjugate and chimeric antigen receptor containing the specified antibody; a nucleic acid encoding the said chimeric receptor; a vector containing the said nucleic acid; a virus containing the said vector; an immune cell containing the said nucleic acid, and either vector or virus are disclosed. The use of the said antibody for the production of a medicinal product, a conjugate, a multifunctional antibody, a tumor diagnostic agent, an immune cell; the use of the specified immunoconjugate for the production of a medicinal product, an agent for the diagnosis of a tumor, an immune cell; using the said immune cell to produce a medicinal product are disclosed.
EFFECT: invention makes it possible to effectively treat diseases associated with BCMA expression.
43 cl, 16 dwg, 4 tbl
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Authors
Dates
2023-07-07—Published
2018-01-23—Filed