SMALL MOLECULE INHIBITORS OF THE PHOSPHORYLATED BCL-2-ASSOCIATED DEATH PROMOTER (BAD) Russian patent published in 2023 - IPC C07D211/06 C07D241/04 C07D213/53 C07D295/96 C07D295/155 C07D295/192 C07D307/52 C07D333/20 C07D413/04 A61K31/445 A61K31/496 A61P35/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to new compounds of general formula (I)

where each R¹ is independently OH, NR¹⁰R¹¹, with each of R¹⁰ and R¹¹ independently selected from C_1-6 alkyl; n is 1, 2 or 3; R^2a and R^2b together with the nitrogen atom to which they are attached form a piperazine substituted with one R⁶ substituent; each R⁶ is independently selected from phenyl which may be substituted with 1–2 substituents selected from halo, C_1-2 alkyl; R³ is phenyl, naphthyl, 5–6 membered heteroaryl containing 1 heteroatom selected from O, N and S, any of which is optionally substituted with one R⁷ substituent selected from halo, -O(C_1-4 alkyl), -C_1-4 haloalkyl or -C(O)NR⁸R⁹; each of R⁸ and R⁹ is independently selected from H or C_3-6 cycloalkyl; or a pharmaceutically acceptable salt thereof.

EFFECT: obtaining new compounds being the inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation that have anti-apoptotic activity and are useful in the treatment of cancer, in particular, breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer, or pancreatic cancer.

14 cl, 22 dwg, 2 tbl, 9 ex