LONG-ACTING DOSAGE FORM CONTAINING RIVASTIGMINE AND A METHOD OF ITS MANUFACTURE Russian patent published in 2023 - IPC A61K9/16 A61K31/27 A61P25/28 B01J13/12 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a sustained-release microsphere for long-acting injectable dosage forms containing one or more active substances selected from the group consisting of rivastigmine and its pharmaceutically acceptable, poorly soluble salts and a biodegradable polymer, and to a long-acting injectable dosage form for the prevention or treatment of Alzheimer's disease, as well as a method for manufacturing a microsphere; and it can also reduce the side effects from the gastrointestinal tract of the patient, which are often observed in conventional oral preparations, and improve the adaptability to the drug intake, thereby maximizing the therapeutic effect, by providing a long-acting injectable dosage form containing a sustained-release rivastigmine microsphere, which has a high content, while effectively regulating the initial explosive drug release.

EFFECT: obtaining long-acting dosage form containing rivastigmine.

16 cl, 12 ex, 10 tbl, 7 dwg