PHARMACEUTICAL COMPOSITION OF THE DELAYED AGENT RELEASING AND A METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to a composition that has a physiologically active peptide of the general formula: where X means acyl-group; R₁, R₂ and R₄ each means aromatic cyclic group; R₃ means a residue of D-amino acid or a group of the formula: where means heterocyclic group; R₅ means a group of the formula where n = 2 or 3, and means amino-group that can be substituted optionally, aromatic cyclic group or O-glycosyl-group; R₆ means a group of the formula where n = 2 or 3, and means amino-group that can be substituted optionally; R₇ means a residue of D-amino acid or azaglycyl-residue; Q means hydrogen atom or lower alkyl-group, or its salt and biodegradable polymer bearing a terminal carboxyl-group. Composition is prepared by dissolving of components mixture in water-insoluble solvent followed by solvent removing. Preparation of delayed releasing ensures to obtain noncontinuous release of peptide for the long time without initial release as compared with the known similar compositions. EFFECT: improved method of preparing, enhanced effectiveness of composition proposed. 25 cl, 9 tbl, 45 ex