FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to a sustained-release preparation for injection containing biodegradable polymer microspheres with donepezil as an active substance, and to a method for its preparation, to a delayed-release pharmaceutical composition from microspheres and high content of donepezil, and to a method of preparing such a composition.
EFFECT: therapeutic effect can be maximally increased, reducing side effects in the gastrointestinal tract, often inherent to conventional drugs for oral administration, and facilitating adherence to the drug treatment regimen by the patients.
8 cl, 17 ex, 5 tbl, 2 dwg
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