METHODS FOR COLORIMETRIC DETECTION OF ENDPOINTS AND MULTIPLE TITRATION SYSTEMS Russian patent published in 2023 - IPC G01N31/16 

FIELD: chemical industry.

SUBSTANCE: group of inventions relates to a system for the quantitative determination of the concentrations of one or more target analytes in a process solution. The automated titration system includes a reactor manifold containing a conditioning manifold and a second liquid mixer, while the reactor manifold is in fluid communication with a sample source and a titrant source for mixing a continuously flowing and renewed sample stream containing an unknown concentration of the first analyte with the first titrant and an unknown concentration of the second analyte with second titrant; a sample pump in fluid communication with the sample source and the reactor manifold, continuously pumping a sample stream from the sample source into the reactor manifold through the sample stream inlet; a first titrant pump in fluid communication with the first titrant source and the reactor manifold for pumping the first titrant into the reactor manifold through the first titrant inlet to contact a continuously flowing and renewing sample stream; a second titrant pump in fluid communication with the second titrant source and the reactor manifold for pumping the second titrant into the reactor manifold through the second titrant inlet to contact a continuously flowing and renewing sample stream; a multi-wavelength detector in fluid communication with the reactor manifold for detecting a first titration endpoint of the reaction between the first analyte and the first titrant and for detecting a second titration endpoint of the reaction between the second analyte and the second titrant, the detector being located downstream of the first and second inlets titrants and is located at a distance from the inputs of the first and second titrants; and a controller in communication with the sample pump, the first titrant pump, the second titrant pump, and the detector. In this case, the conditioning manifold contains the first liquid mixer, and the conditioning manifold is located downstream of the sample flow inlet, while the first titrant inlet and the second titrant inlet are located downstream of the conditioning manifold and upstream of the second liquid mixer, and the second liquid mixer located upstream of the detector. The controller controls the sample pump to set a continuous sample flow rate, controls the first titrant pump to set the flow rate of the first titrant, controls the second titrant pump to set the second titrant to a continuous flow rate, and receives data from the detector to detect the first titration endpoint for the reaction between the first analyte and the first titrant and determining the concentration of the first analyte at the first endpoint of the titration and detecting the second endpoint of the titration for the reaction between the second analyte and the second titrant and determining the concentration of the second analyte at the second endpoint of the titration. Also disclosed is a method for quantifying the concentration of a first target analyte and the concentration of a second target analyte in a sample stream.

EFFECT: group of inventions provides efficient and reliable automated titration for various target analytes.

15 cl, 7 dwg, 1 tbl