HETEROCYCLIC COMPOUND, INTERMEDIATE COMPOUND, A METHOD OF ITS PRODUCTION AND ITS USE Russian patent published in 2023 - IPC C07D471/04 A61K31/437 A61K31/4545 A61K31/5377 A61P11/14 A61P29/00 

FIELD: heterocyclic compounds.

SUBSTANCE: invention relates to heterocyclic compounds of formula I

, where represents ; m is 1, 2, 3 or 4; R³ is H, halogen, C₁-C₆ haloalkyl or C₁-C₆ alkyl; when m is not equal to 1, R³ is independently the same or different; W is a single bond; is phenyl; n is either 1, 2, 3 or 4; R¹ is independently H, halogen, unsubstituted or substituted C₁-C₆ alkyl; where the specified substituted C₁-C₆ alkyl substituted by one to three halogens; and when n is not equal to 1, R¹ is independently the same or different; Q is -NH-C(=O)-R^1-1, -S(=O)₂-N(R^1-9R^1-10), -N(R^1-14R^1-15), -NH-S(=O)₂-R^1-16, unsubstituted or substituted C₃-C₄ cycloalkyl, unsubstituted or substituted C₃-C₆ heterocycloalkyl, or unsubstituted or substituted 5–6-membered heteroaryl; where the specified C₃-C₆ heterocycloalkyl contains 1–3 heteroatoms selected from one or more of O and N; the specified 5–6-membered heteroaryl contains 1–3 heteroatoms selected from N; the said substituted C₃-C₄ cycloalkyl, substituted C₃-C₆ heterocycloalkyl, or substituted 5–6-membered heteroaryl are substituted with one or more substituents independently selected from halo, -OH, and -CN; R² is independently ; where R^2-1 and R^2-2 each independently represents H, unsubstituted C₁-C₆ alkyl; X and Y are each independently methylene, -O-, -N(R^2-3)- or ; R^2-3 and R^2-4 are each independently H or unsubstituted C₁-C₆ alkyl-O-, intermediates and methods of their preparation and use.

EFFECT: obtaining new heterocyclic compounds of formula I which have a high P2X3 antagonistic activity and good selectivity.

26 cl, 8 dwg, 9 tbl, 192 ex