FIELD: chemistry; medicine.
SUBSTANCE: invention relates to the use of N-bornyl- and N-phenchylcarboxamide compounds of the general formula Ia-f and IIa-f, including their spatial isomers, including optically active forms, as inhibitors of orthopoxvirus replication. In formulas Ia-f and IIa-f R=4-ClC6H4, (2R)-Ia and (2S)-Ia; R=4-BrC6H4, (2R)-Ib and (2S)-Ib; R=4-NO2C6H4, (2R)-Ic and (2S)-Ic; R=cyclohexyl, (2R)-Id and (2S)-Id; R=4-CF3C6H4, (2R)-Ie; R=3-pyridyl, (2R)-If; R1=4-ClC6H4, (2S)-IIa; R1=4-BrC6H4, (2S)-IIb; R1=4-NO2C6H4, (2S)-IIc and (2R)-IIc; R1=4-CF3C6H4, (2S)-IId; R1=4-CH3C6H4, (2S)-IIe; R1=4,4-difluorocyclohexyl, (2S)-IIf.
EFFECT: using n-bornil- and n-phenchylcarboxamides as orthopoxvirus replication inhibitors.
1 cl, 3 tbl, 19 ex
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