METHOD OF PREDICTING THE DEVELOPMENT OF SEVERE POSTOPERATIVE HEPATOCELLULAR INSUFFICIENCY WHEN PLANNING EXTENSIVE RESECTIONS Russian patent published in 2023 - IPC A61B6/00 G01T1/164 

FIELD: medicine; medical radiology; oncology; surgery.

SUBSTANCE: invention can be used to predict the development of severe postoperative hepatocellular insufficiency when planning extensive resections. Scintigraphy of the heart and liver in direct projection after a single intravenous bolus injection of 0.5–1.0 ml of technefit containing 200 MBq of the 99 mTc isotope is performed. The blood retention coefficient and the liver retention coefficient are determined between 90 and 210 seconds from the time the bolus is administered according to the following formulas: KRK=α90/α210, where KRK is the blood retention coefficient,α 90 is the value of activity at 90 seconds of the study,α 210 is activity value at the 210th second of the study, CRP=β90/β210, where KRP is liver retention coefficient, β90 is the value of activity at 90 seconds of the study, β210 is the value of activity at 210 seconds of the study. The potential index of the estimated liver residue (PI) is determined by the following formula: PI=KRP/KRK, where PI is the potential index of the estimated liver residue, KRP is the liver retention coefficient, KRK is the blood retention coefficient. With a PI value of 0.01–2.3, the risk of developing severe postoperative hepatocellular insufficiency is defined as high, with an PI value of 2.4–2.6 the risk is defined as medium, with an PI value of 2.7 or more the risk is defined as low.

EFFECT: method provides prediction of the development of severe postoperative hepatocellular insufficiency when planning extensive resections due to heart and liver scintigraphy data.

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